Treatment of non-communicable diseases (NCDs) is particularly challenging in settings affected by humanitarian crises, where insecurity and damaged health systems reduce access to treatment. The evidence base is negligible: a systematic review on the effectiveness of interventions for NCDs in humanitarian settings found just eight studies published over the last 35 years, four of which came from the same refugee camp in Jordan. The diversity of the epidemiology of NCDs and health system characteristics in humanitarian crises preclude a simple “one size fits all” approach. Here, we highlight the key gaps in knowledge and the actions that we believe are required for ensuring NCD care is available to populations in humanitarian crises.